NNT and Multiple Endocrine Neoplasia

At the same time consider here long-term introduction of lidocaine for prevention of arrhythmias in myocardial infarction (Possibly proaritmicheskoe effect of lidocaine, a weakening heartbeat, impaired atrioventricular conduction). Side effects of procainamide: hypotension (associated with ganglioblokiruyuschimi properties procainamide), flushing of face, neck, disturbances atrioventricular conduction, nausea, vomiting, headache, insomnia. When prolonged systematic use of amiodarone say light brown sediments (promelanin and lipofuscin) along the perimeter cornea (usually do not violate the view), as well as deposits in the skin, therefore skin becomes serogoluboy hue and becomes highly sensitive to UV radiation (photosensitivity). Effective with the atrial and ventricular especially when tachyarrhythmias and extrasystoles. This is due to the fact that, by blocking Na + channels in the phase of the plateau (phase, lidocaine shortens this phase, phase 3 (repolarization) starts earlier 3. Contraindicated in glaucoma, prostatic hypertrophy, atrioventricular block II-III degree. These drugs have a selective antifibrillyatornoe action. By reducing the excitability increase the ERP of the Purkinje fibers and fibers of the working myocardium. flutter these agents markedly depress the excitability and here there is little effect on the duration action potential. Phenytoin is particularly effective in arrhythmias caused by cardiac glycosides. In connection with the blockade of Ca2 + channels adrenoceptor amiodarone relaxes and slowed contraction of the heart (reducing Pneumothorax need for cardiac oxygen), and in connection with the blockade aadrenoretseptorov dilates coronary and peripheral vessels, moderately reduces blood pressure. Side effects of lidocaine: a moderate depression of atrioventricular conduction (contraindicated in atrioventricular block II-III degree), irritability, dizziness, paresthesia, tremor. Inhibit atrioventricular conduction. They are used for conversion of atrial fibrillation to sinus rhythm and prevention of atrial fibrillation fibrillation in the future flutter . In addition, these drugs may be effective in ventricular extrasystoles associated with increased automation. Devoid of many side effects, characteristic of amiodarone, but showing the side effects, peculiar blockers. Using drugs possible arrhythmia torsade de pointes (1,52%). Lidocaine reduces excitability and conductivity (less flutter quinidine), decreases automaticity, and reduces ERP Purkinje fibers (The ratio of ERP to action potential duration increases). Side effects blockers: heart failure, bradycardia, impaired atrioventricular conduction, fatigue, toning bronchi (contraindicated in bronchial asthma), peripheral vasoconstriction, enhancement of hypoglycemic agents (Elimination of glucagon action of adrenaline). In particular, amiodarone is highly effective for translation (conversion) and atrial flutter to sinus rhythm and for the prevention of ventricular fibrillation. here lidocaine only ventricular tachyarrhythmias and extrasystoles. Also has a sympatholytic properties. In therapeutic doses of lidocaine here little effect on myocardial contractility, blood pressure, atrioventricular conduction. Preparations subgroups IB - Lidocaine, Valium, phenytoin, unlike drugs subgroups IA smaller influence on the conductivity, do not block the potassium channels («pure» sodium channel blockers) did not increase and decrease the duration of the action potential (respectively decreases ERT). Drugs are effective Present Illness supraventricular arrhythmias, and ventricular premature beats and tachyarrhythmias, but have pronounced arrhythmogenic properties (may cause arrhythmia in Hodgkin's Disease of patients), reduce myocardial contractility.