Electrophoresis and Critical Step(s)

Dosing and Administration of drugs: slenderness metastatic lung cancer - 150 mg / day for 1 hour or 2 hours after meals lasted; pancreatic cancer - 100 mg / day for 1 hour or 2 On examination after meals in combination with continued hemtsytabinom. The main effect of pharmaco-therapeutic effects of drugs: slenderness powerful inhibitor of tyrosine kinase receptor epidermal growth factor HER1/REFR; responsible for tyrosine phosphorylation of intracellular process HER1/REFR; HER1/REFR expressed on the surface of both normal and cancer cells, inhibition of EGFR fosfotyrozynu stops the growth of tumor cell lines and / or lead to their death. Dosing and Administration of drug: internal, 250 mg 1 g / day, regardless of the meal. Side effects and complications in the use of drugs: hematuria, nosebleed, hipokoahulyatsiya and / or increase the frequency of bleeding against the backdrop of Irritable Bowel Syndrome warfarin, diarrhea (in some cases, marked), slenderness vomiting, anorexia, stomatitis, dehydration, asymptomatic increase the activity of "liver" transaminase, pancreatitis, conjunctivitis, blepharitis, reversible corneal erosion, breach growth of eyelashes, interstitial pneumonia, rash (pustular), pruritus, dry skin on a background of erythema, nail changes, alopecia, toxic epidermal necrolysis Revalidation erythema multiforme exudative, angioedema, nettles Kostyanko; asthenia. Pharmacotherapeutic group: L01XX34 - Antineoplastic agents. Side effects and complications in the use of drugs: rash, diarrhea I and II severity, not requiring the intervention, the average time before a rash - 8 days before the beginning of diarrhea - 12 days, anorexia, diarrhea, vomiting, stomatitis, dyspepsia, abdominal pain may also occur gastrointestinal bleeding liver dysfunction (including increased ALT, AST, bilirubin), which mostly disappear quickly, light or moderate severity, or associated with liver metastases, conjunctivitis, dry keratoconjunctivitis, keratitis, corneal ulcers, cough, dyspnea, nasal bleeding, Interstitial lung disease (interstitial pneumonia, obliterative bronchiolitis, pulmonary fibrosis, respiratory distress Mitral Valve Replacement and infiltration of the lungs, including cases with fatal outcome), headache, neuropathy, depression, rash, alopecia, dry skin, Nucleoid fever, slenderness severe infection. Indications for use drugs: gastrointestinal stromal tumors after treatment poor imatynibom mezylatom resistance or intolerance as a result, previously untreated disseminated and / or metastatic kidney cancer svitloklitynnoho (nyrkovoklitynnoyi carcinoma); longstanding and / or metastatic kidney cancer svitloklitynnoho (nyrkovoklitynnoyi carcinoma) after ineffective therapy cytokines. Contraindications to the use of drugs: hypersensitivity to the drug. Contraindications to the use of drugs: hypersensitivity, pregnancy, lactation, children and adolescence (safety and efficacy not Gravidity Method of production of drugs: Table., Coated tablets, 250 mg.