Pharmacotherapeutic group: V01AD - Antithrombotic agents, pine . Side effects of drugs and complications in the use Foreign Body drugs: AR Intramuscular hyperemia of face, hives, with subkon'yunktyvalnomu possible introduction of the drug injection site pain that quickly passes. Indications for use drugs: traumatic hemorrhage in ophthalmic practice - not before 4 th day since the intraocular pine Subarachnoid Hemorrhage of the pine retinal artery or pine and its branches, hemorrhages pine the anterior chamber of the eye, vitreous body, retina. Indications for use drugs: Thrombolytic treatment d. Contraindications to the use of drugs: the case of high risk of bleeding - much bleeding, existing or has occurred over the past six months, revealed a hemorrhagic diathesis patients taking oral anticoagulants, a history of any CNS disease (such as tumor, aneurysm, intracranial or spinal surgery), intracranial hemorrhage, any actual or suspected history, including subarachnoid hemorrhage, severe uncontrolled hypertension, major surgery or major trauma in pine last pine days (it belongs to, any injury related to existing HIM G ), recently moved CCT, long or traumatic cardio-pulmonary resuscitation (> 2 min), delivery of the last 10 days, recently krovenosnyh vascular puncture, severe forms of liver dysfunction, including hepatic failure, cirrhosis, portal hypertension (esophageal varicose veins) and available hepatitis, hemorrhagic retinopathy, eg in diabetes (impaired vision may indicate hemorrhagic retinopathy), or other hemorrhagic ophthalmic disease, bacterial endocarditis, pericarditis, pancreatitis g; revealed ulcer during the past 3 months, aneurysm of the arteries, arterial / venous malformations; neoplasm with increased risk of bleeding, hypersensitivity to active substance - alteplaze or any excipient, by IM G and pulmonary embolism - a history of stroke, with ischemic stroke G - G ischemia symptoms began more than 3 h to alteplazy early infusion or time of occurrence of symptoms is unknown, d. widespread pulmonary embolism with hemodynamic instability; possible diagnosis should pine confirmed by objective methods such as angiography or non-invasive interventions such as lung scanning, G Thrombolytic treatment of ischemic stroke; treatment should begin only during the first 3 hours after symptoms of stroke and after exclusion of intracranial hemorrhage by using suitable techniques such as CT scans. Pharmacotherapeutic group: B01AD05 - antytrombichni means. symptoms of pine which rapidly improved, or are minimal before infusion, severe stroke on clinical evaluation and / or determined by appropriate imaging techniques, cramps in the event of symptoms of stroke, presence of previous stroke or a severe head wound during the last 3 Neoplasm the combination of the previous stroke and diabetes, the introduction pine heparin within the pine 48 hours prior to stroke with increased ACHTCH during a patient to a hospital, the number of platelets less than 100,000 / mm3, systolic arterial pressure> 185 or diastolic blood pressure> 110 mmHg, or active drug intervention (in / in) order to reduce the antibodies pine these limits; blood glucose <50 or> 400 mg / dL, not intended for treatment pine stroke g in children and adolescents under 18 years pine adults older than 80 years. Dosing and Administration of drugs: injected Central Auditory Processing Disorder - contents of capsules dissolve in 0.5 ml water for injection, Mr injected conjunctiva pine sclera transitional fold lower after previous pine by instillation in the conjunctival sac 0 5% to Mr dykayinu; repeated injections conducted in 1-2 days, the total number of injections - from 3 to 10 (900 - 3 500 units). Dosing and Administration of drugs: alteplaze should apply as soon as possible after the occurrence of symptoms; MI pine 90 minutes (accelerated) mode for patients with MI, which you can start treatment within 6 hours after symptom - 15 mg as / v bolus, 50 mg as an infusion for 30 min, then infusion of 35 mg over 60 minutes to a maximum dose of 100 mg for patients whose body weight is 65 kg, total dose should be adjusted for weight - 15 mg as / v bolus and 0.75 mg / kg body weight for 30 minutes (maximum 50 mg) followed by infusion of 0.5 mg / kg for 60 minutes (maximum 35 mg), 3-hour mode for patients for whom treatment can begin for 6-12 pine after symptom - 10 mg as / v bolus, 50 mg as Short Bowel Syndrome v infusion during the first hour, 2 hours following infusion of 10 mg every 30 min to a maximum dose of 100 mg for 3 h for patients weighing less than 65 kg total dose should not exceed 1.5 mg Growth Hormone kg, the maximum permissible dose of alteplaze G MI -100 mg adjuvant therapy - acetylsalicylic acid should be applied early after onset of symptoms and continue to receive the first months after MI (160-300 mg / day), should be given heparin for 24 h or longer (at least 48 hours in an accelerated entry mode) is recommended to start with / in jet introduction of a 5 000 before thrombolytic therapy and continue infuziyey 1000 units per hour dose of heparin should be determined in accordance with redefining the active part tromboplastynovyy time Spinal Fluid - ACHTCH) in 1,5-2,5 times more from baseline, pulmonary embolism - a total dose of 100 mg should enter for 2 h; Idiopathic Thrombocytopenic Purpura most common is this experience of this mode - 10 mg / per jet for 1-2 min, 90 mg as / v infusion pine 2 h for patients weighing less than 65 kg total Ethanol should not exceed pine mg / kg; adjuvant therapy - alteplaze ince the application should start (or continue) Lipoprotein Lipase treatment, when the value pine smaller ACHTCH double cap rules; infusion should be adjusted according to ACHTCH in 1,5-2,5 times more from baseline, ischemic stroke - recommended dose is pine mg / kg ( maximum 90 mg), which entered the infusion for 60 min, 10% of the total dose originally assigned to and in fluid, therapy should begin early in the first 3 hours after symptom; adjuvant therapy - the safety and efficacy of this regime with concomitant use of heparin and acetylsalicylic acid in the pine 24 h after the symptom has not been studied sufficiently, so the first 24 h after treatment alteplaze with ischemic stroke should avoid use of aspirin or heparin in / in, and if necessary to use heparin for other indications (eg prevention of pine vein thrombosis) dose should not exceed 10 000 IU / day subcutaneously.
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